The skin is increasingly used as a non-invasive substitute to measure molecule concentration in the blood. However, the concentrations on the skin or in the layer immediately below (subcutaneous space) are a distorted situation than what is in the blood. Compartmental or physiological model are dynamic models that can translate nutrient or drug concentrations as they integrate transport and permeation terms across tissues. Continuous glucose monitors are implanted subcutaneously to read glycemia every 5 minutes for 14 continuous days. They integrate models letting them to be just calibrated at the factory. The models that we offer come from nutrient or pharma experience.